Eikon is applying measurement of protein dynamics in living cells to discover new mechanisms and develop new therapies

Eikon is uncovering the potential of Single Molecule Tracking (SMT) across the drug discovery process. (ref) Our technology uniquely positions us to discover breakthrough medicines.

The ability to image and quantify the dynamic movement of proteins reveals novel druggable biology for difficult targets. These mechanisms can be used across the drug discovery paradigm in high-throughput screens, as secondary assays, or to optimize compounds against a given target. The broad utilization of protein dynamics, coupled with a full complement of drug discovery assay systems, will enable discovery of new therapeutics for previously undruggable targets.


Cell Biology

Medicinal Chemistry


Single Molecule Tracking

Our pipeline is designed to achieve impactful therapeutics for unmet medical needs.

Meet the team pioneering SMT in drug discovery

References on application of SMT to biology


Guided nuclear exploration increases CTCF target search efficiency. Hansen AS, Amitai A, Cattoglio C, Tjian R, Darzacq X. (2020) Nat Chem Biol. 16(3):257-266.

Imaging dynamic and selective low-complexity domain interactions that control gene transcription. Chong S, Dugast-Darzacq C, Liu Z, Dong P, Dailey GM, Cattoglio C, Heckert A, Banala S, Lavis L, Darzacq X, Tjian R. (2018) Science. 361(6400). pii: eaar2555

Live cell imaging reveals the dynamics of telomerase recruitment to telomeres. Schmidt JC, Zaug AJ, Cech, TR. (2016) Cell 166, 1188-1197.

Real-time imaging of Huntingtin aggregates diverting target search and gene transcription. Li L, Liu H, Dong P, Li D, Legant WR, Grimm JB, Lavis LD, Betzig E, Tjian R, Liu Z. (2016) Elife. 5:e17056.

Single-molecule tracking in live cells reveals distinct target-search strategies of transcription factors in the nucleus. Izeddin I, Récamier V, Bosanac L, Cisse II, Boudarene L, Dugast- Darzacq C, Proux F, Bénichou O, Voituriez R, Bensaude O, Dahan M, Darzacq X. (2014) Elife, 10.7554/eLife.02230.

Real time dynamics of RNA Polymerase II clustering in live human cells. Cisse I.I., Izzedin I., Causse S.Z., Boudarene L., Muresan L., Dugast- Darzacq C., Hajj B., Dahan M., Darzacq X. (2013) Science 341, 664- 7.